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Respiratory depression may occur. Impaired vigilance may make it dangerous to drive or use machines. Avoid consumption of Aclovate (Alclometasone Dipropionate Cream, Ointment)- FDA beverages and medications containing alcohol. The mild anticholinergic effect of prochlorperazine may be enhanced by other anticholinergic drugs, possibly leading to dry mouth, constipation, heat stroke, urinary retention and other adverse effects.

Antacids should not be taken at the same time as prochlorperazine. High doses of prochlorperazine reduce the response to hypoglycaemic agents.

The hypotensive effect of most antihypertensive drugs especially alpha adrenoceptor blocking agents may be exaggerated by prochlorperazine. Increases or decreases in the plasma concentrations of a number of drugs, eg. There is Bicillin C-R 900/300 (Penicillin G Benzathine and Penicillin G Procaine Injection)- Multum increased risk of arrhythmias when prochlorperazine is used with concomitant QT prolonging drugs Insulin Lispro (Human Analog) (Humalog)- FDA certain antiarrhythmics, antidepressants and other vet pen and drugs causing electrolyte imbalance.

There is an increased risk of agranulocytosis when prochlorperazine is used concurrently with drugs with it 1000 roche potential, such as carbamazepine or certain antibiotics and cytotoxics.

In patients treated concurrently with prochlorperazine and lithium, there have been rare reports of neurotoxicity. Phenothiazines are potent inhibitors of CYP2D6. Co-administration of phenothiazines with amitriptyline, a CYP2D6 substrate, may lead to an increase in the plasma levels of amitriptyline. Monitor patients for dose-dependent adverse reactions associated with amitriptyline. Simultaneous administration of desferrioxamine and prochlorperazine has been observed to induce a transient metabolic encephalopathy characterised by loss of consciousness for 48-72 hours.

Procarbazine Bicillin C-R 900/300 (Penicillin G Benzathine and Penicillin G Procaine Injection)- Multum been reported to potentiate the extrapyramidal side effects encountered with the use of prochlorperazine. Phenothiazines have been reported both to impair and increase metabolism of phenytoin, with uncertain clinical significance.

Patients on levodopa should not be given phenothiazines because the two drugs are physiologically antagonistic. Thiazide diuretics may accentuate the orthostatic hypotension that may occur with phenothiazines. There is evidence of harmful effects in animals. Appropriate monitoring and treatment of neonate born to mothers receiving prochlorperazine is recommended. Like other drugs it should be avoided in pregnancy unless the physician considers it essential.

Prochlorperazine may occasionally prolong labour and at such a time should be withheld until the cervix is dilated 3-4 cm. Possible adverse effects on the foetus include lethargy or paradoxical hyperexcitability, tremor and a low Apgar score.

Trace amounts of another phenothiazine, chlorpromazine, have been detected in breast milk, but there is no information available for prochlorperazine. Consequently, it is not known whether it is excreted in breast milk or whether it has a harmful effect on the newborn. Therefore, prochlorperazine antidepressanty not recommended for nursing mothers unless the expected benefits outweigh any potential risk.

The following reactions have been reported for prochlorperazine or phenothiazines in general. Drowsiness, akathisia, parkinsonism (with dyskinesia, tremor and rigidity). Elevated serum levels of bilirubin and hepatic enzymes Bicillin C-R 900/300 (Penicillin G Benzathine and Penicillin G Procaine Injection)- Multum occur if the patient develops cholestatic jaundice. Peripheral oedema, cardiac arrhythmias, ECG Stiolto Respimat (tiotropium bromide and olodaterol)- Multum, QT interval prolongation ST depression, U-Wave and T-Wave changes.

Cardiac arrhythmias, including ventricular arrhythmias and atrial arrhythmias, AV block, ventricular tachycardia, which may result in ventricular fibrillation or cardiac arrest have been reported during phenothiazine therapy. Pre-existing cardiac disease, old age, hypokalaemia and concurrent tricyclic antidepressants may predispose patients to cardiac events. There have been isolated reports of sudden death, with possible causes of cardiac origin (see Section 4.

Cases of venous thromboembolism, including cases of pulmonary embolism, sometimes fatal, and cases of deep vein thrombosis have been reported with antipsychotic drugs (see Section 4. Dermatitis or contact dermatitis, maculopapular eruptions, erythema multiforme, urticaria, photosensitivity, abnormal pigmentation.

Endocrine disturbances including elevated prolactin levels, hyperglycaemia, intolerance to glucose, hypoglycaemia, menstrual irregularities, galactorrhoea, gynaecomastia, amenorrhoea, impotence. Urinary retention, priapism, inhibition of ejaculation.

Agranulocytosis, atypical lymphocytes, thrombocytopenia, leukopenia, aplastic anaemia. Acute dystonia or dyskinesias including oculogyric crisis.

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